Organix, a Massachusetts based corporation established in 1986, is a pioneer of Contract Research in Synthetic Organic and Medicinal Chemistry in the United States.  Organix is recognized internationally as a premier provider of outstanding services at the discovery end of the drug development pathway.  We provide Custom Synthesis of molecules in all structural classes, Design and Synthesis of New Chemical Entities, Structure Activity Relationship Studies, Hit-to-Lead Studies, and Development and Optimization of Synthetic Procedures and Design and Synthesis of Drug Conjugates in which active NCEs are tethered to HRP, PEG, HPMA-polymers, HPMA-copolymers, or other large molecules. These tethered NCEs can also be designed to cleave and release the NCE in situ.

Organix owns and operates a state-of-the-art facility, staffed by highly skilled Ph.D. organic chemists. Organix can assist you in the pursuit of your research and development goals.

We invite you to join our list of over 120 satisfied clients that include almost every multinational pharmaceutical company as well as established and emerging biopharmaceutical companies.

Services

Contract Research and Development, 
Custom Synthesis in Organic and Medicinal Chemistry

Organix is your partner for contract research and development in all areas of Organic and Medicinal Chemistry. We provide an opportunity to accelerate your advances from discovery to the pharmaceutical product pipeline. Organix is a partner in your project. Senior management is involved in your project at all stages to provide a comprehensive strategic outsourcing relationship.

Comprehensive and effective communication and collaboration with our clients is a hallmark of our success.

We offer

• Contract Research and Development in Synthetic Organic Chemistry
• Custom Synthesis of Organic Molecules
• Hit-to-Lead Studies
• Lead Generation and Optimization
• Structure Activity Relationship Studies to discover new molecular entities and optimize lead compounds
• Collaborative projects to discover new molecular entities designed for specific functions
• Design, Evaluation and Optimization of Synthetic Procedures
• Design and Synthesis of New Molecular Entities
• Isolation, Identification and Synthesis of Natural Products
• Research and Synthesis of Controlled Substances
• Design and Synthesis of Cationic Lipids and "Lipidoids"
• Microsphere Synthesis and Microencapsulation

History

Organix is a privately held company founded in 1986 by three experienced synthetic organic chemists. In the 1980s outsourcing of sensitive and confidential drug discovery programs was highly unusual. A distrust for placing sensitive and valuable intellectual property in the hands of an unrelated contract organization pervaded the pharmaceutical industry.  In the ‘80s the exponential growth of Biotech had not yet begun. At that time, the idea of an independent CRO conducting sensitive research for multinational pharmaceutical companies in the US was largely unheard of! However, Organix quickly established contractual relationships with two pharmaceutical multinational corporations and proved that we could deliver outstanding quality in a reliable and highly confidential manner. Both corporations engaged Organix for many years and one remains a client to the present time.  In the ensuing decades, Organix has grown and has attracted clients from all sectors. Our clients’ common need has been the synthesis of small molecules. In 1996 Organix purchased land and established a state-of-the-art facility designed expressly for organic chemistry. These fully equipped facilities have been recognized by large and small pharma as outstanding for housing and conducting modern chemical operations.

Organix provides synthetic organic and medicinal chemistry services at the discovery end of the drug development process. There are numerous CROs that provide chemistry services; there are few whose goal is to work hand-in-hand with clients in a relationship that allows total ongoing control of goals, priorities and synthesis activities. Our mission is to provide services that meet or exceed the services that you may have available in-house. We pride ourselves in our ability to react to changing programmatic demands as if we were in the laboratory down the corridor from your own. Communication and collaboration is a hallmark of our success. Organix contributes as a scientific intellectual partner to achieve your goals in an efficient, timely and cost-effective manner. An important aspect of our services is that Organix’ scientists assigned to the project solve synthetic problems as they arise and often improve synthetic procedures when appropriate.